Curtailed Tcell activation curbs effector differentiation and generates CD8<sup></sup> T cells with a naturallyoccurring memory stem cell phenotype
نویسندگان
چکیده
1 Laboratory of Translational Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy 2 Institution of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK 3 Translational Tumor Immunology Group, Ludwig Center for Cancer Research, Epalinges, Switzerland 4 Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy 5 Department of Medical Biotechnologies and Translational Medicine (BioMeTra), University of Milan, Italy, Milan 6 Humanitas Flow Cytometry Core, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
منابع مشابه
Curtailed T‐cell activation curbs effector differentiation and generates CD8+ T cells with a naturally‐occurring memory stem cell phenotype
Human T memory stem (TSCM ) cells with superior persistence capacity and effector functions are emerging as important players in the maintenance of long-lived T-cell memory and are thus considered an attractive population to be used in adoptive transfer-based immunotherapy of cancer. However, the molecular signals regulating their generation remain poorly defined. Here we show that curtailed T-...
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